HIV Drug Resistance Tests: An Update on Methods for Calculating Phenotypic Fold Change from a Viral Genotype
نویسندگان
چکیده
منابع مشابه
HIV drug resistance tests: an update on methods for calculating phenotypic fold change from a viral genotype.
To the Editor—In a recently published article, Hirsch et al. [1] reviewed HIV drug resistance assays used in clinical practice and described a “virtual phenotype” that correlates genotypic data on the plasma HIV-1 RNA of a candidate gene with a large database of paired phenotypes and genotypes. Although the authors cite other bioinformatics systems that generate a calculated fold change (FC), o...
متن کاملMutagenetic tree Fisher kernel improves prediction of HIV drug resistance from viral genotype
Starting with the work of Jaakkola and Haussler, a variety of approaches have been proposed for coupling domain-specific generative models with statistical learning methods. The link is established by a kernel function which provides a similarity measure based inherently on the underlying model. In computational biology, the full promise of this framework has rarely ever been exploited, as most...
متن کاملGeno2pheno: estimating phenotypic drug resistance from HIV-1 genotypes
Therapeutic success of anti-HIV therapies is limited by the development of drug resistant viruses. These genetic variants display complex mutational patterns in their pol gene, which codes for protease and reverse transcriptase, the molecular targets of current antiretroviral therapy. Genotypic resistance testing depends on the ability to interpret such sequence data, whereas phenotypic resista...
متن کاملAn Update on Ovarian Aging and Ovarian Reserve Tests
Ovaries are the female organs that age more quickly than other tissues such as the uterus, the pituitary gland or pancreas. Different from males, an interesting question is why and how the females lose fertility so rapidly. During the aging process, both the number and quality of the oocytes in the ovaries decrease and reach to a point beyond that no more viable offspring may be produced and th...
متن کاملGeno2pheno: Interpreting Genotypic HIV Drug Resistance Tests
nonnucleoside reverse transcriptase (RT) inhibitors (NRTI and NNRTI, respectively) and protease inhibitors (PI). (See the “Abbreviations” sidebar for other abbreviations in this article). Even with the currently recommended combination therapies consisting of three to five drugs, few patients achieve longterm suppression of plasma virus levels below detectable limits. Drug resistance1 is a majo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2009
ISSN: 1058-4838,1537-6591
DOI: 10.1086/597016